Best Rock Instrumental Performance „A Day in the Life” – Jeff Beck „Warped Sister” – Booker T. Jones „Playing With Fire” – Brad Paisley „Mr. Surfer Goes Jazzin'” – The Brian Setzer Orchestra „Now We Run” – Steve Vai
Best Rock Song „The Fixer” – Pearl Jam Matt Cameron, Stone Gossard, Mike McCready & Eddie Vedder, autor tekstu „I’ll Go Crazy If I Don’t Go Crazy Tonight” – U2 Bono, Adam Clayton, The Edge & Larry Mullen Jr., autor tekstu „21 Guns” – Green Day Billie Joe Armstrong, Mike Dirnt & Tré Cool, autor tekstu „Use Somebody” – Kings of Leon Caleb Followill, Jared Followill, Matthew Followill & Nathan Followill, autor tekstu „Working on a Dream” – Bruce Springsteen
Best Rock Album Black Ice – AC/DC Live from Madison Square Garden – Eric Clapton & Steve Winwood 21st Century Breakdown – Green Day Big Whiskey and the GrooGrux King – Dave Matthews Band No Line on the Horizon – U2
Muzyka alternatywna Best Alternative Music Album Everything That Happens Will Happen Today – David Byrne & Brian Eno The Open Door EP – Death Cab for Cutie Sounds of the Universe – Depeche Mode Wolfgang Amadeus Phoenix – Phoenix It’s Blitz!