Protein 1 sa tetratrikopeptidnim i ankirinskim ponavljanjem jest protein koji je kod ljudi kodiran genom TRANK1 sa hromosoma 3.
Aminokiselinska sekvenca Dužina polipeptidnog lanca je 2.925 aminokiselina, а molekulska težina Da. 336 221
1020304050 MWDPRAARVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVK GYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMS SDSIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKD RLPRNIHVPELSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIG PYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKDGDGCTVLHVVAA HSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKI NSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLLHK NFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEV LLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCL IDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDT PLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTL MHILFQKGMLKRVKKLLDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLA WNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQGSFKSVPCGATA RTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVE VDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVG LGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLK KLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLD KGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDI VLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPR CYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDT TATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKF HVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDS IEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIF VTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFV TSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEE AEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPA LIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSL FSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQ AELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTID KQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDS GLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKE KIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTS TDSREENRPLVEVPLDKPGSSQGRSLMVNPEMYKLLNGELKQLYTAITRA RVNLWIFDENREKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPA EWIAQGDYYAKHQCWKVAAKCYQKGGAFEKEKLALAHDTALSMKSKKVSP KEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQLSAQLCERLGKIRDAA YFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAVEKYEEMLK TKTLPISKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLK SRKRLAEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLG AARLNVARDSDIEHTKDILREALDICYQTGQLSGIAEAHFLQGVILRDFQ KLRDAFFKFDTLNHSAGVVEALYEAASQCEAEPEKILGLAPGGLEILLSL VRALKRVTNNAEKEMVKSCFEFFGISQVDAKYCQIAQNDPGPILRIIFDL DLNLREKKTKDHFLIMTDQVKLALNKHLLGRLCQITRSLLGKTYRGVCMR FIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGLLLEAKKVFPK ILAEELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEILK PNYKSFRFYRFALKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYP EEFEKLLHQEEDNYNRELKALESEKDERGRGRGSRIKGIEGKFGMLAPNR DDENMDKTHLCFIRLLENCIDQFYVYRNPEDYKRLFFRFMNVLIKRCKEP LIPSIGNTVALLEFQFIHCGVVLARLWKNVILCLPKSYIALLHYWEFLFS KKDKELGDVFSIIQEYKPKDVTRAIQDFRFHLSYLAKVLCGYENVNFNVL LDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCKPLLYRHFREIES RLQLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDEEYLM DCDWRWDPVHTKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEM DELALEDRDHVLATILSQKQRKASIQRKLRRACLVVSLCISWRRRVGTQM ERVREEAREPRAGNFKKADVDRTQCDLCGVKFTRGPENYFSPSKAFEGAA SEVAVLSRAELEREECQERNSESYEQHIHLEHHQRQQVAYQKYSEFFHEK VDPAIDEGKLVVQDIEQSVWIHSHVGSKEHSHMLQKVQEHIKRVSDMVED LYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTETRLKKEGIVQEDDY ENEVEDFGELRPRRRSRKCGKQRKY
Klinički značaj Studijom asocijacije koja obuhvata čitav genom, TRANK1 je povezan sa bipolarnim poremećajem.
Reference
Dopunska literatura
Kategorija:Geni na hromosomu 3 Kategorija:Ljudski proteini Kategorija:Proteomika