UCI WorldTour 2021 var den ellevte utgaven av UCI WorldTour.
Kalender Kalenderen ble offentliggjort i juli 2020. Tour of California og RideLondon-Surrey Classic ble aldri registrert av arrangørene.
DatoRittVinner19.–24. jan. Tour Down Under Avlyst31. jan.Avlyst21.–27. feb. UAE Tour (2021) Tadej Pogačar (UAD)<small>Etapper: van der Poel, Ganna (ITT), Pogačar, Bennett, Vingegaard, Bennett, Ewan27. feb. Omloop Het Nieuwsblad (2021) Davide Ballerini (DQT)6. mar. Strade Bianche (2021) Mathieu van der Poel (AFC)7.–14. mar. Paris–Nice (2021) Maximilian Schachmann (BOR)<small>Etapper: Bennett, Bol, Bissegger (ITT), Roglič, Bennett, Roglič, Roglič, Cort10.–16. mar. Tirreno–Adriatico (2021) Tadej Pogačar (UAD)<small>Etapper: van Aert, Alaphilippe, van der Poel, Pogačar, van der Poel, Würtz Schmidt, van Aert (ITT)20. mar. Milano–Sanremo (2021) Jasper Stuyven (TFS)22.–28. mar. Catalonia rundt (2021) Adam Yates (INS)<small>Etapper: Kron, Dennis (ITT), Yates, Chaves, Kämna, Sagan, De Gendt24. mar. Tredagers i De Panne (2021) Sam Bennett (DQT)26. mar. E3 Saxo Bank Classic (2021) Kasper Asgreen (DQT)28. mar. Gent–Wevelgem (2021) Wout van Aert (TJV)31. mar. Dwars door Vlaanderen (2021) Dylan van Baarle (INS)4. apr. Flandern rundt (2021) Kasper Asgreen (DQT)5.–10. apr. Baskerland rundt (2021) Primož Roglič (TJV)<small>Etapper: Roglič (ITT), Aranburu, Pogačar, Izagirre, Honoré, Gaudu11. apr. Paris–RoubaixUtsatt18. apr. Amstel Gold Race (2021) Wout van Aert (TJV)21. apr. La Flèche Wallonne (2021) Julian Alaphilippe (DQT)25. apr. Liège–Bastogne–Liège (2021) Tadej Pogačar (UAD)27. apr. – 2. mai Romandie rundt (2021) Geraint Thomas (INS)<small>Etapper: Dennis (ITT), Sagan, Colbrelli, Soler, Woods, Cavagna (ITT)8.–30. mai Giro d'Italia (2021) Egan Bernal (INS)<small>Etapper: Ganna (ITT), Merlier, van der Hoorn, Dombrowski, Ewan, Mäder, Ewan, Lafay, Bernal, Sagan, Schmid, Vendrame, Nizzolo, Fortunato, Campenaerts, Bernal, Martin, Bettiol, Yates, Caruso, Ganna (ITT)30. mai–6. jun. Critérium du Dauphiné (2021) Richie Porte (INS)<small>Etapper: Van Moer, Pöstlberger, Colbrelli, Lutsenko, Thomas, Valverde, Padun, Padun6.–13. jun. Sveits rundt (2021) Richard Carapaz (INS)<small>Etapper: Küng (ITT), van der Poel, van der Poel, Bissegger, Carapaz, Kron, Urán (ITT), Mäder Tour de France (2021) Tadej Pogačar (UAD)<small>Etapper: Alaphilippe, van der Poel, Merlier, Cavendish, Pogačar (ITT), Cavendish, Mohorič, Teuns, O'Connor, Cavendish, van Aert, Politt, Cavendish, Mollema, Kuss, Konrad, Pogačar, Pogačar, Mohorič, van Aert (ITT), van Aert31. jul. Clásica de San Sebastián (2021) Neilson Powless (EFN)9.–15. aug. Polen rundt (2021) João Almeida (DQT)<small>Etapper: Bauhaus, Almeida, Gaviria, Almeida, Arndt, Cavagna (ITT), van den Berg14. aug. – 5. sep. Vuelta a España (2021) Primož Roglič (TJV)<small>Etapper: Roglič (ITT), Philipsen, Taaramäe, Jakobsen, Philipsen, Cort, Storer, Jakobsen, Caruso, Storer, Roglič, Cort, Sénéchal, Bardet, Majka, Jakobsen, Roglič, López, Cort, Champoussin, Roglič (ITT)15. aug. EuroEyes Cyclassics Avlyst22. aug. Bretagne Classic Ouest-France (2021) Benoît Cosnefroy (ACT)23x23pk|Benelux Benelux Tour (2021) Sonny Colbrelli (TBV)<small>Etapper: Merlier, Bissegger (ITT), van der Hoorn, Merlier, Ewan, Colbrelli, Mohorič10. sep. Grand Prix Cycliste de Québec Avlyst12. sep. Grand Prix Cycliste de Montréal Avlyst19. sep. (2021) Jasper Philipsen (AFC)3. okt. Paris–Roubaix (2021) Sonny Colbrelli (TBV)9. okt. Il Lombardia (2021) Tadej Pogačar (UAD)14.–19. okt. Tour of GuangxiAvlyst
UCI WorldTeam Endringer fra 2020 er at Intermarché-Wanty-Gobert Matériaux overtar CCC Team sin lisens. I tillegg er det en del navne- og sponsorendringer. KodeNavnLandACTAG2R Citroën TeamAPTAstana-Premier TechTBVTeam Bahrain VictoriousBEXTeam BikeExchangeBOHBora - hansgroheCOFCofidisDQTDeceuninck-Quick StepDSMTeam DSMEFNEF Education-NippoGFCGroupama-FDJTJVTeam Jumbo-VismaIGDIneos GrenadiersISNIsrael Start-Up NationIWGIntermarché-Wanty-Gobert MatériauxLTSLotto SoudalMOVMovistar TeamTQATeam Qhubeka AssosTFSTrek-SegafredoUADUAE Team Emirates
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