Enterobakterijski fag T4 je bakteriofag koji može da inficira bakteriju -{E. coli}-. Njegov dvolančani DNK genom je oko 169 kbp dugačak i sadržan je u ikosaedarskoj glavi, poznatoj kao kapsid. T4 je relativno veliki fag, približno 90 nm u širok i 200 nm dugačak (većina fagova ima dužinu u opsegu od 25 do 200 nm). Vlakna njegovog repa omogućavaju vezivanje za ćeliju domaćina. Rep T4 faga je šupalj, tako da nukleinska kiselina prolazi kroz njega pri ulasku u ćeliju. T4 ima jedino sposobnost sprovođenja litičkog, a ne i lizogenog životnog ciklusa.
Reference
Literatura -{ T4 Bacteriophage Infection Process Animations - Copyright © 2004-2009 by Karam, J., Petrov, V., Nolan, J., Chin, D., Shatley, C., Krisch, H., and Letarov, A. The T4-like phages genome project. . (The T4-like phage full genomic sequence depository) Mosig, G., and F. Eiserling. 2006. T4 and related phages: structure and development, R. Calendar and S. T. Abedon (eds.), The Bacteriophages. . Oxford. (Review of phage T4 biology). (Indication of prevalence and T4-like phages in the wild) (Characterization of a T4-like phage)
(Review of phage T4, from the perspective of its genome) (Overview of the RB49 genome, a T4-like phage) (T4 phage application in biotechnology for studying protein interaction) (Indication of the prevalence of T4-type sequences in the wild) (Historical description of the isolation of the T4-like phages T2, T4, and T6) (Nearly complete list of then-known T4-like phages) (Overview of various T4-like phages from the perspective of their genomes) (Comparison of the genomes of various T4-like phages) Karam, J. D. et al. 1994. Molecular Biology of Bacteriophage T4. ASM Press. Washington, DC. (The second T4 bible, go here, as well as Mosig and Eiserling, 2006, to begin to learn about the biology T4 phage). Eddy, S. R. 1992. Introns in the T-Even Bacteriophages. Ph.D. thesis. University of Colorado at Boulder. (Chapter 3 provides overview of various T4-like phages as well as the isolation of then-new T4-like phages) Surdis, T.J "et al" Bacteriophage attachment methods specific to T4, analysis, Overview. Mathews, C. K., E. M. Kutter, G. Mosig, and P. B. Berget. 1983. Bacteriophage T4. American Society for Microbiology, Washington, DC. (The first T4 bible; not all information here is duplicated in Karam et al., 1994; see especially the introductory chapter by Doermann for a historical overview of the T4-like phages). Russell, R. L. 1967. Speciation Among the T-Even Bacteriophages. Ph.D. thesis. California Institute of Technology. (Isolation of the RB series of T4-like phages) (rare type of translational regulation characterized in T4) (T4-like phage isolation, including that of phage Ox2)
Vidi još T4 -{rII}- sistem
Spoljašnje veze
Категорија:Бактериофаги