Les compagnies de chemins de fer d'Amérique du Nord (regroupant Mexique, Canada et États-Unis) sont nombreuses, pouvant représenter quelques kilomètres de voies comme des milliers. La présente liste présente les chemins de fer en activité.

Les compagnies sont réparties par classes. Les chemins de fer américains de classe I, représentant les principales compagnies quant aux revenus, sont listées en gras ci-dessous.

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Transport de fret A Aberdeen and Rockfish Railroad (AR) Aberdeen, Carolina and Western Railway (ACWR) Acadiana Railway (AKDN) Adrian and Blissfield Rail Road (ADBF) Agence métropolitaine de transport (AMT) Airlake Terminal Railway (ALT) Akron Barberton Cluster Railway (AB) Alabama and Florida Railway (AF) Alabama and Gulf Coast Railway (AGR) Alabama and Tennessee River Railway (ATN) Alabama Railroad (ALAB) Alabama Southern Railroad (ABS) Alabama Warrior Railway (ABWR) Alamo Gulf Coast Railroad (AGCR) Alaska Railroad (ARR) Albany and Eastern Railroad (AERC) Albany Port Railroad (APD) Alexander Railroad (ARC) Aliquippa and Ohio River Railroad (AOR) Allegheny Valley Railroad (AVR) Alliance Terminal Railroad (ATR) Almanor Railroad (AL) Alton and Southern Railway (ALS) AN Railway (AN) Angelina and Neches River Railroad (ANR) Ann Arbor Railroad (AA) Apache Railway (APA) Appalachian and Ohio Railroad (AO) Appanoose County Community Railroad (APNC) Arcade and Attica Railroad (ARA) Arizona and California Railroad (ARZC) Arizona Central Railroad (AZCR) Arizona Eastern Railway (AZER) Arkansas–Oklahoma Railroad (AOK) Arkansas and Missouri Railroad (AM) Arkansas Midland Railroad (AKMD) Arkansas Southern Railroad (ARS) Arkansas, Louisiana and Mississippi Railroad (ALM) Ashland Railway (ASRY) Ashtabula, Carson and Jefferson Railroad (ACJR) AT&L Railroad (ATLT) Atlantic and Western Railway (ATW) Austin Western Railroad (AWRR)

B B&H Rail Corporation (BH) Ballard Terminal Railroad (BDTL) Baltimore and Ohio Chicago Terminal Railroad (BOCT) Baton Rouge Southern Railroad (BRS) Batten Kill Railroad (BKRR) Bauxite and Northern Railway (BXN) Bay Coast Railroad (BCR) Bay Colony Railroad (BCLR) Bay Line Railroad (BAYL) Beech Mountain Railroad (BEEM) Belt Railway of Chicago (BRC) Belvidere and Delaware River Railway (BDRV) Bessemer and Lake Erie Railroad (BLE) BG&CM Railroad (BGCM) Bi-State Development Agency Railroad (BSDA) Big 4 Terminal Railroad (BFRR) Bighorn Divide and Wyoming Railroad (BDW) Birmingham Southern Railroad (BS) Black River and Western Corporation (BRW) Blacklands Railroad (BLR) Blackwell Northern Gateway Railroad (BNG) Bloomer Shippers Connecting Railroad (BLOL) BNSF Railway (BNSF) Boise Valley Railroad (BVRR) Boone and Scenic Valley Railroad (BSVY) Boot Hill and Western Railway (BHWY) Border Pacific Railroad (BOP) Brandon Railroad (BRAN) Brandywine Valley Railroad (BVRY) Brownsville and Rio Grande International Railroad (BRG) Buckingham Branch Railroad (BB) Buffalo and Pittsburgh Railroad (BPRR) Buffalo Southern Railroad (BSOR) Burlington Junction Railway (BJRY) Butte, Anaconda and Pacific Railway (RARW) (Rarus Railway)

C C&NC Railroad (CNUR) C&S Railroad (CSKR) Caddo Valley Railroad (CVYR) Caldwell County Railroad (CWCY) California Northern Railroad (CFNR) Camp Chase Industrial Railroad (CCRA) Canadien National (CN) et filiales : (BCR) Grand Trunk Western Railroad (GTW) Lakeland & Waterways Railway (LWR) Mackenzie Northern Railway (MKNR) Savage Alberta Railnet (SAR) Wisconsin Central Ltd. (WC) Canadien Pacifique Kansas City (CPKC) et filiales Canadien Pacifique (CP) et filiales : Dakota, Minnesota and Eastern Railroad (DME) Delaware and Hudson Railway (DH) Soo Line Railroad (SOO) St. Lawrence and Hudson Railway (STLH) Kansas City Southern Railway (KCS) Kansas City Southern de México (KCSM) Caney Fork and Western Railroad (CFWR) Cannon Valley Railroad (CVRC) Canton Railroad (CTN) Cape Fear Railways (CF) Cape May Seashore Lines (CMSL) Carolina Coastal Railway (CLNA) Carolina Piedmont Railroad (CPDR) Carolina Southern Railroad (CALA) Carrizo Gorge Railway (CZRY) Carrollton Railroad (CARR) Cascade and Columbia River Railroad (CSCD) Cedar Rapids and Iowa City Railway (CIC) Cedar River Railroad (CEDR) Central California Traction Company (CCT) Central Illinois Railroad (CIRY) Central Indiana and Western Railroad (CEIW) Central Midland Railway (CMR) Central Montana Rail, Inc. (CM) Central New England Railroad (CNZR) Central New York Railroad (CNYK) Central Oregon and Pacific Railroad (CORP) Central Railroad of Indiana (CIND) Central Railroad of Indianapolis (CERA) Central Washington Railroad (CWA) CG Railway (CGR) Charlotte Southern Railroad (CHS) Chattahoochee Bay Railroad (CHAT) Chattahoochee Industrial Railroad (CIRR) Chattooga and Chickamauga Railway (CCKY) Chemin de fer de la Gaspésie (CCFG) Chemin de fer Arnaud (CFA) Chemin de fer Baie des Chaleurs (CBC) Chemin de fer Cartier (Cartier) Chemin de fer Charlevoix (CFC) Chemin de fer Central Vermont (CV) Chemin de fer Lanaudière (CFL) Chemin de fer de la Matapédia et du Golfe (CFMG) Chemin de fer de l'Outaouais (CFO) Chemin de fer QNS&L (QNSL) Chemins de fer Québec-Gatineau (CFQG) Chemin de fer de la Rivière Romaine (CFRR) Chemin de fer de Roberval-Saguenay (RS) Chemin de fer Saint-Laurent & Atlantique (SLQ) Chemin de fer Sartigan (CFS) Chesapeake and Albemarle Railroad (CA) Chesapeake and Indiana Railroad (CKIN) Chestnut Ridge Railroad (CHR) (Chestnut Ridge Railway) Chicago–Chemung Railroad (CCUO) Chicago Central and Pacific Railroad (CC) Chicago Port Railroad (CPC) Chicago Rail Link (CRL) Chicago SouthShore and South Bend Railroad (CSS) Chicago Terminal Railroad (CTM) Chicago, Fort Wayne and Eastern Railroad (CFE) Cimarron Valley Railroad (CVR) City of Prineville Railway (COP) Claremont Concord Railroad (CCRR) Clarendon and Pittsford Railroad (CLP) Cleveland Commercial Railroad (CCRL) Cleveland Works Railway (CWRO) Clinton Terminal Railroad (CTR) Cloquet Terminal Railroad (CTRR) CMC Railroad (CMC) Coffeen and Western Railroad (CAEG) Colorado and Wyoming Railway (CW) Columbia and Cowlitz Railway (CLC) Columbia Basin Railroad (CBRW) Columbia Terminal Railroad (CT) Columbus and Greenville Railway (CAGY) Columbus and Ohio River Rail Road (CUOH) Commonwealth Railway (CWRY) Conecuh Valley Railroad (COEH) Connecticut Southern Railroad (CSO) Coopersville and Marne Railway (CPMY) Copper Basin Railway (CBRY) Corpus Christi Terminal Railroad (CCPN) Crab Orchard and Egyptian Railroad (COER) CSX Transportation (CSXT)

D D&I Railroad (DAIR) Dakota Northern Railroad (DN) Dakota Southern Railway (DSRC) Dakota, Minnesota and Eastern Railroad (DME) Dakota, Missouri Valley and Western Railroad (DMVW) Dallas, Garland and Northeastern Railroad (DGNO) Dardanelle and Russellville Railroad (DR) De Queen and Eastern Railroad (DQE) Decatur Junction Railway (DT) Delaware Coast Line Railroad (DCLR) Delaware–Lackawanna Railroad (DL) Delaware and Hudson Railway (DH) Delray Connecting Railroad (DC) Delta Southern Railroad (DSRR) Delta Valley and Southern Railway (DVS) Denver Rock Island Railroad (DRIR) Depew, Lancaster and Western Railroad (DLWR) Detroit Connecting Railroad (DCON) Doniphan, Kensett and Searcy Railway (DKS) Dubois County Railroad (DCRR) Duluth, Missabe and Iron Range Railway (DMIR) Duluth, Winnipeg and Pacific Railway (DWP) Durbin and Greenbrier Valley Railroad (DGVR)

E East Brookfield and Spencer Railroad (EBSR) East Camden and Highland Railroad (EACH) East Chattanooga Belt Railway (ECTB) East Cooper and Berkeley Railroad (ECBR) East Erie Commercial Railroad (EEC) East Jersey Railroad and Terminal Company (EJR) East Penn Railroad (ESPN) East Tennessee Railway (ETRY) East Troy Electric Railroad (METW) Eastern Alabama Railway (EARY) Eastern Idaho Railroad (EIRR) Eastern Illinois Railroad (EIRC) Eastern Maine Railway (EMRY) Eastern Washington Gateway Railroad (EWG) Effingham Railroad (EFRR) El Dorado and Wesson Railway (EDW) Elgin, Joliet and Eastern Railway (EJE) Elk River Railroad (ELKR) Elkhart and Western Railroad (EWR) Ellis and Eastern Company (EE) Escanaba and Lake Superior Railroad (ELS) Esquimalt and Nanaimo Railway ( Evansville Western Railway (EVWR) Everett Railroad (EV)

F Falls Road Railroad (FRR) Farmrail Corporation (FMRC) Ferromex (FXE) Finger Lakes Railway (FGLK) First Coast Railroad (FCRD) Flats Industrial Railroad (FIR) Florida Central Railroad (FCEN) Florida East Coast Railway (FEC) Florida Midland Railroad (FMID) Florida Northern Railroad (FNOR) Florida West Coast Railroad (FWCR) Fordyce and Princeton Railroad (FP) Fore River Transportation Corporation (FRVT) Fort Smith Railroad (FSR) Fort Worth and Dallas Belt Railroad (FWDB) Fort Worth and Dallas Railroad (FWDR) Fort Worth and Western Railroad (FWWR) Fredonia Valley Railroad (FVRR) Fremont Northwestern Railroad (FNW) Fulton County Railroad (FC) Fulton County Railway (FCR)

G Galveston Railroad (GVSR) Garden City Western Railway (GCW) Gary Railway (GRW) Gateway Eastern Railway (GWWE) Georges Creek Railway (GCK) Georgetown Railroad (GRR) Georgia and Florida Railway (GFRR) Georgia Central Railway (GC) Georgia Midland Railroad (GMR) Georgia Northeastern Railroad (GNRR) Georgia Southwestern Railroad (GSWR) Georgia Woodlands Railroad (GWRC) Gettysburg and Northern Railroad (GET) Gloster Southern Railroad (GLSR) GNP Railway (GNPR) Golden Isles Terminal Railroad (GITM) Golden Triangle Railroad (GTRA) Grafton and Upton Railroad (GU) Grainbelt Corporation (GNBC) Grand Elk Railroad (GDLK) Grand Rapids Eastern Railroad (GR) Grand Trunk Western Railroad (GTW) Great Lakes Central Railroad (GLC) Great Northwest Railroad (GRNW) Great River Railroad (GTR) Great Smoky Mountains Railroad (GSM) Great Walton Railroad (GRWR) Great Western Railway of Colorado (GWR) Green Mountain Railroad (GMRC) Greenville and Western Railway (GRLW) Grenada Railway (GRYR) Gulf, Colorado and San Saba Railway (GCSR)

H Hainesport Industrial Railroad (HIRR) Hampton and Branchville Railroad (HB) Heart of Georgia Railroad (HOG) Heritage Railroad (HR) High Point, Thomasville and Denton Railroad (HPTD) Hollis and Eastern Railroad (HE) Hondo Railway (HRR) Honey Creek Railroad (HCRR) Hoosier Southern Railroad (HOS) Housatonic Railroad (HRRC) Huntsville and Madison County Railroad Authority (HMCR) Huron and Eastern Railway (HESR)

I Idaho and Sedalia Transportation Company (ISRC) Idaho Northern and Pacific Railroad (INPR) Illinois and Midland Railroad (IMRR) Illinois Central Railroad (IC) Illinois Railway (IR) Illinois Western Railroad (ILW) Indian Creek Railroad (ICRK) Indiana and Ohio Railway (IORY) Indiana Eastern Railroad (IERR) Indiana Harbor Belt Railroad (IHB) Indiana Northeastern Railroad (IN) Indiana Rail Road (INRD) Indiana Southern Railroad (ISRR) Indiana Southwestern Railway (ISW) Iowa Interstate Railroad (IAIS) Iowa Northern Railway (IANR) Iowa Northwestern Railroad (IANW) Iowa River Railroad (IARR) Iowa Traction Railroad (IATR)

J Jefferson Warrior Railroad (JEFW) Juniata Valley Railroad (JVRR)

K Kankakee, Beaverville and Southern Railroad (KBSR) Kansas and Oklahoma Railroad (KO) Kasgro Rail Lines (KRL) Kaw River Railroad (KAW) Kendallville Terminal Railway (KTR) Kentucky and Tennessee Railway (KT) Keokuk Junction Railway (KJRY) Kettle Falls International Railway (KFR) Kiamichi Railroad (KRR) Kiski Junction Railroad (KJR) Klamath Northern Railway (KNOR) Knoxville and Holston River Railroad (KXHR) Kosciusko and Southwestern Railway (KSRY) KWT Railway (KWT) Kyle Railroad (KYLE)

L Lake County Railroad (LCR) Lake Michigan and Indiana Railroad (LMIC) Lake State Railway (LSRC)